Application of a Novel Magnetic Immunoassay System to Point of Care Diagnostics: Development and Validation of a High Sensitivity C-Reactive Protein (hsCRP) Assay.

Proceedings of the 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Dresden, June 10-14, 2014.

Shaw, M, Laitinen, M, Savonen, M and Soikkeli M.

Utilising antibodies labelled with paramagnetic nanoparticles (Magnetic ImmunoAssay, MIA) is a novel means of increasing the sensitivity and precision of lateral flow immunoassays while enabling the development of an inexpensive robust reader. The magnetic particles can be detected and quantified with great accuracy while the direct interaction between the magnetically labelled antibodies and the reader’s electronics creates a system unique in its sensitivity and robustness. Furthermore, magnetometers have a wider dynamic ranges then optical systems, reducing the need for sample dilution while retaining sensitivity. This presentation will describe the application of this technology to a clinically important analyte; C-reactive protein.

Measurement of Super-Paramagnetic Nanoparticle Labels in
Immunological Point-of-Care Tests.

Lekkala, J Mäkiranta, J and Laitinen, M. 2011. 6th Nordic Magnetic Conference, Pori, Finland, October 5th, 2011

Novel Measurement Method for Magnetic Particles
Mäkiranta, J., Verho, J., Lekkala, J. and Matintupa, N. 2006
EMBC 2006, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. New York, USA Conf Proc IEEE Eng Med Biol Soc.;1:4598-4601.

Modeling and Simulation of a Magnetic Nanoparticle Sensor.
Mäkiranta, J. and Lekkala, J. 2005. 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Shanghai, China.
Conf Proc IEEE Eng Med Biol Soc.;2:1256-9.

Optimization of a Novel Magnetic Nanoparticle Sensor.
Mäkiranta, J., Lekkala, J. 2006. XVIII IMEKO World Congress, Metrology for Sustainable Development. September 17-22 2006, Rio de Janiero, Brazil.